Regenerative Science: Biomaterials in Wound Healing  |  October 15, 2010

Novel approaches in wound healing seek to supply to the wound with biologic factors that are thought to be absent in the chronic wound. This support for regenerative wound repair is being reinforced by sizeable grants for such research, like the pair of recent U.S. Army grants totaling $760,000 awarded to Lakshmi Nair at the University of Connecticut to study the regenerative repair of musculoskeletal tissue, like skin, cartilage and bone.

In improper wound healing, cells can show either an exaggerated or inadequate response to molecular healing signals, leading to problematic wound site inflammation or stalled wound healing. Dr. Nair’s approach seeks to ‘modulate’ the local wound site with regenerative biomaterials, specifically, a polysaccharide compound that adapts to the irregular geometries characteristic of tissue defects, while acting as carriers for known wound-healing cells and protein growth factors.  Also in the works is a protein-based injectable biomaterial that seeks to regenerate compromised bone and cartilage. Using organic molecules like these, Dr. Nair hopes to deliver cost-effective, biologically active treatments that will rescue improper wound healing and stimulate the replacement of lost bone and cartilage.

– Jessica Duncan, AlloSource Product Manager – Burn and Wound Care

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